LRRK2 and autophagy: what motor regulation and cargo analysis can tell us about neuronal homeostasis and neurodegeneration

Our laboratory is focused on understanding the dynamics of organelle motility along the cellular cytoskeleton, driven by molecular motors: cytoplasmic dynein, kinesins, and myosins. The active transport of membrane-bound organelles is required for intracellular biosynthetic and endocytic trafficking in most eukaryotic cells.  However, the highly polarized morphology of neurons, with axons that can extend over distances of up to one meter, make these cells uniquely dependent on motor-driven transport.

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Thursday, September 30, 2021 - 13:00 ET
Erika Holzbaur (University of Pennsylvania)